EnamelBase: Mouse Models

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Projects and Data Links Amelogenesis: A Primer Mouse Models Protocols

The following table describes a suite of innovative mouse models, including amelogenesis-stage specific constitutive and inducible Cre drivers, reporters, conditional knock-out, and targeted mutant models. These models target structural and proteolytic proteins of the enamel matrix, trans-membrane ion transporters, and intracellular proteins associated with vesicular transport.

To cite this data: Please use the links under the Deposited By column to find the Project page for that mouse model. Then click the Share and cite button and use the text under “Data Citation”.

Mutant Allele	Group	Mouse Chromosome (ENSEMBLE)	Map and genotyping protocol			MMRRC Depository ID	Verification Method	Deposited By
MMP20 flox	LoxP insertion	Ch. 9	MAP WT	MAP MUTANT	Genotyping Protocol	68130	LoxP Recombination	Klein/Joester
KLK4 flox	LoxP insertion	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	68131	LoxP Recombination	Klein/Joester
AMTN flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68132	LoxP Recombination	Klein/Joester
AMELX flox	LoxP insertion	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68129	LoxP Recombination	Klein/Joester
ENAM flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	LoxP Recombination	Klein/Joester
AMBN flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	LoxP Recombination	Klein/Joester
ODAM flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	n/a	Klein/Joester
CLTC Flox	LoxP insertion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	68093	LoxP Recombination	Diekwisch
AMELX-E3-GGG	Targeted mutation	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68127	Locus sequencing	Klein/Joester
AMELX-E5-GGG	Targeted mutation	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68128	Locus sequencing	Klein/Joester
AMBN-A254_Y255insX	Targeted mutation	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	Locus sequencing	Klein/Joester
XYZ-CreERT2	Knock out/Knock-in	TBA	MAP WT	MAP MUTANT	Genotyping Protocol	n/a	n/a	Klein/Joester
Proser2-EYFP	Knock out/Knock-in	Ch. 2	MAP WT	MAP MUTANT	Genotyping Protocol	n/a	n/a	Klein/Joester
AMBN-Cre	Knock out/Knock-in	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68135	TdTomato expression	Klein/Joester
AMBN-IRESCre	IRES	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67446	LacZ expression	Paine
AMBN-CreERT2	Knock out/Knock-in	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting approval	TdTomato expression	Klein/Joester
AMBN-p2A-EGFP	p2A	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68134	GFP expr. in secretory ameloblasts	Klein/Joester
AMELX-p2A-Cre	p2A	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68136	TdTomato expression	Klein/Joester
AMELX-p2A-CreERT2	p2A	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	n/a	Klein/Joester
Slc13a5R337X	Targeted mutation	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	67433	Sanger sequencing	Hu
Slc13a519del	Spontaneous Deletion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	67434	Sanger sequencing	Hu
Slc13a5Flag	Targeted insertion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	68041	Sanger sequencing, Flag expression by IHC	Hu
OdaphC41X	Targeted mutation	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67431	Sanger sequencing	Hu
OdaphIns	Spontaneous Insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67432	Sanger sequencing	Hu
KLK4-Cre	Knock out/Knock-in	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	68133	TdTomato expression	Klein/Joester
KLK4-CreERT2	Knock out/Knock-in	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	TdTomato expression	Klein/Joester
KLK4-p2A-mCherry	p2A	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	mCherry in maturation stage ameloblasts	Klein/Joester
ODAM-IRESCre	IRES	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67402	LacZ expression	Paine